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Kinase SARfari

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BioFocus DPI has launched its latest knowledge base, Kinase SARfari. The fully integrated data repository and research workbench focuses on the protein kinase family of drug targets. This powerful tool combines chemical and biological data from internal proprietary and public sources in a single, dynamic system.

Protein kinases are an important class of drug targets often pursued by the pharmaceutical industry because of the vital role they play in regulating cancer and inflammatory diseases. Kinase SARfari enables the user to design compounds and focused libraries against specific protein kinases and to rapidly optimise compound discovery through exploration of structure-activity relationships.

Through effective integration and mapping of data from diverse biological and chemical sources, Kinase SARfari increases productivity and enhances knowledge discovery. The system comes populated with a number of databases, including: all human protein kinase sequences and a large collection of model organism orthologs; protein kinase clinical candidates and FDA-approved drugs; more than 700 3D structural domains from the Protein Data Bank (PDB) with complete binding-site focused structural superposition; and more than 14,000 protein kinase compounds and more than 57,000 structure-activity relationship (SAR) screening and ADMET data points from BioFocus DPI’s StarLite database.