Simcyp Simulator 13

Certara, a provider of software and scientific consulting services to improve productivity and decision-making from drug discovery through drug development, has released version 13 of its Simcyp Simulator. The solution enables the quantitative prediction of drug-drug-interactions and pharmacokinetic-pharmacodynamic outcomes in virtual populations.

Features include a full physiologically-based pharmacokinetic (PBPK) model for monoclonal antibodies and therapeutic proteins with significant practical applications, and the inclusion of a non-linear plasma protein and red blood cell binding facility. Furthermore, the integration of a novel sophisticated IVIVC tool to handle in vitro - in vivo correlations of dissolution for various solid oral dosage forms enhances the scope of the simulator in the divisions of formulation and pharmaceutics.

Analysis and opinion

Robert Roe investigates some of the European projects focusing on preparing today’s supercomputers and HPC programmers for exascale HPC


The Jülich Supercomputing Centre (JSC) at Forschungszentrum Jülich in Germany has been operating supercomputers of the highest performance class since 1987. Tim Gillett talks to Norbert Attig and Thomas Eickermann


Gemma Church investigates how simulation and modelling de-risks the detection and extraction of geothermal energy resources


Robert Roe investigates the importance of upgrading legacy laboratory informatics systems and the benefits this provides to scientists