Thermo Fisher Scientific has integrated Matrix Science’s Mascot search engine for protein identification with its BioWorks software.
The Sequest search algorithm from the University of Washington, (a component of BioWorks software) and Mascot are the two most widely accepted search engines in the field for protein identification and PTM characterisation.
This integration will enable users to consolidate identification results from the two search engines and cross-validate the results, taking advantage of the complementary information provided by each. Studies have shown that different search engines match different spectra, resulting in a large overlap and some unique protein identifications for each. Including both search engines in the same software platform provides a new level of confidence in protein identification.