InteRNA Genomics and Applied Biosystems will co-market InteRNA's small RNA bioinformatics pipeline, miR-Intess, for users of Applied Biosystems' Solid System that enables massively parallel sequencing.
The Applied Biosystems Solid System is a genetic analysis platform that enables ultra-high-throughput (U-HTP) or massively parallel sequencing (MPS) of clonally amplified DNA fragments linked to beads. The sequencing methodology is based on sequential ligation with dye-labeled oligonucleotides. The ultra-high-throughput capability and the unmatched accuracy inherent in the Solid System, coupled with broad application flexibility, provide a system for advancing genome research and personalised genomics, where each individual can have its own genome sequenced.
While the generation of MPS data can be outsourced to a number of sequencing service providers, data processing and interpretation requires highly skilled bioinformaticians and a dedicated computational infrastructure - a challenge for many organisations. InteRNA Genomics delivers complete, up-to-date and ready-to-interpret analyses of raw sequencing data, allowing the researcher to focus on the biological problem at hand. The informatics solutions are modular and easily customised, enabling development of data analysis pipelines that take into account specifics of every individual project.
The basic miR-Intess pipeline generates extensive tabular as well as graphical output. Besides sample and sequencing statistics, comprehensive data on known and candidate novel microRNAs (miRNAs) are provided, allowing simultaneous digital expression profiling and small RNA discovery. Furthermore, links to miRNA target predictions and public databases are provided. Customised solutions and pipeline extensions are available on request.