Boston University's Cardiovascular Proteomics Center (CPC) Core Laboratory has chosen Nonlinear Dynamics' Progenesis software for its label-free LC-MS and 2D data analyses
Progenesis LC-MS v1.1 offers users a fast and visual approach for label-free, quantitative LC-MS analysis. The CPC Core Laboratory at Boston University had early access to the technology and collaborated on the final development stages to help fine tune the finished product. In research presented by Dr David Perlman at the American Society for Mass Spectrometry (ASMS) meeting, the Progenesis LC-MS software facilitated the analyses of LC-MS data obtained from whole-heart homogenate and was able to rapidly identify, from this complex biological sample, significant nitrite dose-dependent alterations in the cardiac proteome. These findings were associated with improved heart function under conditions that model myocardial infarction and may directly lead to the development of novel therapeutic strategies in the treatment and prevention of cardiovascular disease.
Professor Mark McComb, the director of the CPC Core Laboratory, said: 'Our laboratory collaborates with a diverse group of investigators on a wide range of clinically relevant projects ranging from highly-focused protein and post-translational modification (PTM) characterisation to large-scale studies of changes in protein and PTM expression. As part of our bioinformatics platform, we have adopted Progenesis LC-MS and Progenesis SameSpots, because they offer a powerful and sensitive means to identify changes in label-free, quantitative experiments. Furthermore, the software is particularly well designed, such that we may easily train our collaborative groups to interrogate their own data and mine more adequately for low-level changes thus increasing the likelihood of discovering novel findings.'