BIOINFORMATICS

High Content Analyzer

5 January 2009

Genedata

Genedata has enhanced its high content data analysis platform, Genedata Screener, with the addition of High Content Analyzer. As screening scientists are confronted with ever increasing volumes of complex HCS data, visualisation and analysis tools are required that ensure reliability, comparability and consistency of results from HCS experiments. The ability to interactively process, analyse, and review results throughout the workflow is also crucial for informed decision making and reliable hit list generation. Genedata Screener is an open, modular and scalable enterprise solution which addresses these screening demands. The Screener High Content Analyzer module combines HCS and HTS workflows in a single integrated application and provides a flexible and consistent solution for all screening processes.

High Content Analyzer features streamlined processing, systematic quality control and optimised management of HCS data. Due to its open architecture, it can flexibly capture and load assay data from any plate-based HCS instrument or image analysis software and can interface with in-house instrumentation and existing IT infrastructure. The collected information is then managed in a single application. Users can efficiently process multi-featured data sets ranging from one to more than a thousand plates. Experimental problems can be quickly and automatically detected through a combination of built-in algorithms, summary statistics and targeted visualisations. Specific quality issues can be identified and remedied on the complete data set using drill-downs to original HCS images.

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