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Medical Institute prescribes microarray gene expression analysis tool

29 October 2008



The Johns Hopkins Medical Institute has acquired a multi-seat license of Nexus Expression, a tool for microarray gene expression analysis.

Dr Chris Cheadle, director of the Lowe Family Genomics Core at Johns Hopkins Bayview Medical Center, said: 'Nexus Gene Expression represents for us the next step in microarray data analysis software. It combines statistical rigour at the back end while allowing the user maximum flexibility at the front end allowing him/her to view any selected subset of genes in heat map form for all samples in a project with immediate data capture and annotation linkouts readily available at all stages of the analysis.'

Cheadle added: 'In addition, Nexus provides both functional annotation and enrichment analysis, as well as gene set analysis (using a GSEA-like algorithm) in real time and also allows the user to input custom lists of genes for advanced signature analysis. We are encouraging our clients to consider the use of this tool for comprehensive microarray data mining.'

Nexus Expression is a platform independent product and supports all array platforms including Affymetrix, Agilent, Illumina, Roche NimbleGen, and custom arrays. With single mouse clicks, the user can cluster genes and samples to discover expression patterns, simultaneously compare expression profiles of multiple comparisons alongside gene annotations, display significant genes in affected biological processes, perform enrichment analysis to identify genes that are significantly overrepresented in a population.

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